Neoderm and its application in the treatment of skin diseases

Diseases of the skin neyroallergicheskoy nature - a common pathology, only a stepping piodermitam and fungal infections. This group includes eczema, atopic dermatitis, atopic dermatitis, urticaria, vasculitis, drug and food-drug reaction, etc. (1, 2).

Persistent symptoms of dermatoses neyroallergicheskih is different severity itching. As a result, multiple scratches are formed, which are often complicated by a purulent or mycotic infection.

The uncontrolled use of antibiotics is not always justified the appointment of cytotoxic agents, drugs and immunosupresivnyh glucocorticosteroid hormones are a cause of increasing incidence of candidiasis of the skin and mucous membranes. Due to the widespread use of topical steroids in dermatology creams and ointments, the cases of complications of bacterial and Candida neyroallergodermatozov infection. Reported clinical features neyrodermatozov have led to the creation of formulations external use (ointments, creams, lotions, etc.) that have anti-inflammatory, antipruritic, antibacterial and antimycotic activity. (3 - 6).

, содержащие клобетазола пропионат), сильные (0,1% мазь Элоком, содержащая мометазона фуроат, 0,1% крем Неодерм , содержащий триамцинолона ацетонид и др.), умеренно сильные (0,1% крем Целестодерм, содержащий бетаметазона валерат, 0,1% крем Локоид, содержащий гидрокортизона бутират и др.) и слабые (0,01% крем Синалар, содержащий флуцинолон ацетонид и др.) Glucocorticoid drugs outdoors, depending on their biological activities are divided into: very strong (0.05% cream, ointment Psoriderm containing clobetasol propionate), strong (0.1% ointment Elokim, mometasone furoate containing 0.1% cream Neoderm, containing triamcinolone acetonide, etc.), moderately strong (0.1% cream Tselestoderm containing betamethasone valerate 0.1% cream Lokoid containing hydrocortisone butyrate, etc.) and weak (0.01% Cream Sinalar containing flutsinolon acetonide and etc.)

For the treatment of microbial eczema and neyrodermatozov, complicated by bacterial and Candida infections, it is better to use the combined resources for external use, containing, besides glucocorticoid activity of various antibiotics, antimycotics, antiseptics, and sulfur. These include - gioksizon (hydrocortisone acetate and oxytetracycline hydrochloride), oksikort (hydrocortisone and oxytetracycline) sinalar H (fluotsinolon and neomycin), tselestoderm B (betamethasone valerate, garamitsin) diprogent (betamethasone dipropionate and gentamicin sulfate), kortomitsetin (hydrocortisone acetate and chloramphenicol), vipsogal (betamethasone dipropionate, acetonide fluotsinolona, ​​gentamicin sulfate salicylic acid, panthenol) travokort (izokonazolnitrat diflukortolon and valerate) mikozolon (miconazole and deperzolon) sibikort (hydrocortisone and chlorhexidine), aurobin (prednisolone kapronat, Triclosan, lidocaine), dermozolon (prednisone and yodgidroksihinolin) Lorinden C (yodgidroksihinolin and flumetazon) sinalar K (fluotsinolon and kliohinol) sikorten plus (galometazon and triclosan); neoderm (gramicidin, neomycin sulfate, nystatin, triamcinolone acetonide), pimafukort (Hydrocortisone, natamycin and neomycin), triderm (betamethasone dipropionate, Gentamicin sulfate, clotrimazole), sulfodekortem (hydrocortisone acetate and precipitated sulfur).

Neoderm is a cream, 1 g of which is contained gramicidin - 0.25 mg, neomycin sulfate - 2.5 mg, nystatin - 100 000 IU and triamcinolone acetonide - 1 mg. Therefore, the cream has anti-inflammatory, antiallergic, antipruritic, antibacterial, antimycotic action. The drug can be applied to the moist surface of the lesions and prescribe for diaper rash. Indications for use are neoderma neyroallergicheskie dermatoses, including complicated by bacterial and Candida infections, and candidiasis of the skin.

╩ при лечении экземы, атопического дерматита, осложненных бактериальной инфекцией, и кандидоза кожи. The purpose of the study - to evaluate the therapeutic efficacy of the drug "Neoderm" in the treatment of eczema, atopic dermatitis complicated by bacterial infection, and candidiasis of the skin.

We observed 42 patients with different pathologies of the skin. Age surveyed - 14-49 years old. Men was 18, women - 24. Patients had a limited form of true eczema (14) and atopic dermatitis (11), complicated by pyoderma, candidiasis skin folds (6), candidal paronychia (7) and balanoposthitis (4). When the true disease process localized eczema on the skin of the hands (9 pers.) And stop (5 pers.) Characterized by a polymorphic rash, including pustular, hyperemia, edema, infiltration, moist, multiple purulent and serous-purulent crusts. Patients with eczema complained of severe itching, burning and pain in the lesion. Clinic affected skin is very reminiscent of purulent pathology - piodermity.

The clinical picture of atopic dermatitis was presented erythematous-scaly lesions irregular in shape and located on the trunk and extremities. In areas which are localized on the flexion surface of the elbows and knees, it was possible to note a vivid congestion, edema, infiltration, lichenification, the phenomenon of mild soak, multiple excoriations (mostly on the periphery of the lesion), pustular rash and layering elements of pus and sero- purulent crusts. All of the patients indicated the itching, worse at night and poor sleep. In 7 out of 11 surveyed identified white dermographism.

The defeat of the nail ridges finger was of the multiple (5-6 fingers) and was shown a typical clinic (redness, swelling nail ridges, tenderness, pus from the selection drop in pressure on the roller). Paronychia diagnosed in women employed in the processing of fruits and vegetables (3 persons) and washing dishes (4 pers.)

Candida intertrigo was localized in the interdigital folds of fingers (4 people) and under the breasts (2 pers.) Patients with lesions of the interdigital folds were employed in the confectionery industry and processing of fruits and vegetables. Skin lesions under the breasts were represented by large, irregular shapes with sharp edges, slightly damp shiny surface, infiltrated lesions bordered border exfoliated epidermis.

A similar clinic lesion could be observed in the interdigital folds, of course, with the centers of the smaller area with less severe infiltration and edema.

When balanoposthitis affected skin had a bright pink-red color, was infiltrated and slightly moist. Lesions differed less clear-cut boundaries, compared with intertrigo. In two patients it was possible to observe the gray-white plaque. Patients intertrigo and balanoposthitis itching. Age candidal disease ranged from 2 to 4 weeks. The diagnosis of candidiasis of the skin confirmed tuberculosis microscopy and bacteriological studies.

Patients with eczema and atopic dermatitis was administered standard therapy clinic based disease. External treatment in all cases is to apply to affected skin 2-3 times a day of preparation "Neoderm" within 10-14 days. Patients were under our observation for 2 weeks.

Analyzing the data, one should note a positive effect on Neoderma active manifestations of the disease. Positive effects of the drug in reducing the intensity of the sensation of itching in patients with eczema on the 2-3rd day, atopic dermatitis - a 2-day 4, interdigital intertrigo folds - to 1-2-day, intertrigo under the breasts - 2 4-day and balanoposthitis - to 2-3rd day of Neoderma.

As a result of drug cessation of itching in the lesions occurred: eczema - after 6-8 days, with atopic dermatitis - 7-9 days, with interdigital intertrigo folds - in 4-6 days, with intertrigo under the breasts - through 5 - 7 days, with balanoposthitis - 5-6 days. Burning and pain in the lesions that occurred with eczema and atopic dermatitis, pyoderma complications, as well as paronychia, stopped at the 3-4th days of treatment.

Along with the positive dynamics of the sensations of itching in patients with eczema and atopic dermatitis did not appear new elements of the rash, the affected skin is pale, stopped Moisture (2 - 3 day), decreased edema (3-4th day), infiltration (6-10 - day), peeling (4-6th day) in the foci, we observed the formation and separation of septic and serous-purulent crusts (4-5th day) and epithelialization of cracks. By 12-14 day treatment clinical remission occurred in 5 patients (eczema - 3 people, atopic dermatitis - 2 persons), a significant clinical improvement - in 17 patients (eczema - 10 people, atopic dermatitis - 7 persons) and clinical improvement - in 3 patients (eczema - 1 person, atopic dermatitis - 2 people). It should be noted that the use of Neoderma possible to eliminate secondary pyoderma within 4-6 days of treatment.

In the interdigital intertrigo folds of fingers (4 pax) clinical improvement achieved within 7-10 days. Somewhat slower pathological process was resolved with the defeat of skin folds under the breasts. Symptoms of inflammation (redness, swelling, infiltration) significantly decreased to 8.4 day and permitted to 12-14 day follow-up.

Good results in the treatment of Candida paronychia. Under the influence of the drug there was a decrease of hyperemia (2-3rd day), the cessation of discharge from under the nail shaft (3-4th day), decreased edema (3-5th day), pain (2-3rd day .) Complete resolution of paronychia finger in the observed patients was achieved for the 10-14th day of treatment.

In the immediate results of treatment of balanoposthitis, the resolution of congestion - to 8-day 10, edema - to 5-7th day of infiltration - for 10-12 days, clinical improvement noted at 12-14 days of therapy.

Performed a clinical study evaluating the efficacy of the drug "Neoderm" eczema and atopic dermatitis complicated by bacterial infection, candidal paronychia fingers, intertrigo of small and large folds of skin, balanoposthitis indicates a high therapeutic effectiveness of this tool. In the treatment of patients within 2 weeks of a limited form of eczema and atopic dermatitis, the following data: clinical recovery occurred in 20%, a significant clinical improvement - a 68% clinical improvement - 12% of cases.

The rest of the observed patients had clinical remission.

The content of the cream "Neoderm" triamcinolone acetonide provides anti-inflammatory, antiallergic, antipruritic effect of gramicidin and neomycin sulfate - an antibacterial effect, nystatin - antikandidozny effect.

As expected, the combined topical preparations characterized by a high clinical activity as compared to products containing one of the components. This is understandable: after elimination of bacterial or mycotic infections glucocorticosteroid that is present in the product facilitates the rapid removal of inflammation in the lesion focus, reducing the duration of treatment (4-6). Neoderm can be used in the treatment of many dermatoses neyroallergicheskogo genesis and especially its use is indicated in Medicine complicated by bacterial and Candida infections, as well as in the treatment of superficial forms of candidiasis and piodermitov skin. You should not use the drug for longer than 2 weeks (6,7).

Appointing Neoderm patients should be considered contraindications to the use of the drug and to remember the possibility of side effects. We do not recommend use of the drug hypersensitivity to its components, viral and parasitic skin lesions, burns, ulcers, perioral dermatitis, acne, rosacea, skin atrophy, vascular fragility and pregnancy.

Using Neoderma, like most of corticosteroids can cause the development of contact dermatitis, dry skin, hypertrichosis, perioral dermatitis, skin atrophy.

No side effects in our patients during treatment with high probability can be attributed to strict adherence to our instructions for using the drug.

Thus, an effective Neoderm combination drug topical and well tolerated. It should be more widely used in the treatment neyroallergodermatozov, complicated by bacterial and mycotic infections, and candidiasis of the skin.

Literature

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